It depends on your specific use cases, of course, but my general feeling is I doubt it. There are probably very few applications involving “retrieve some data and plot it” where SQLite isn’t more than fast enough. There are innumerable applications doing that sort of thing with SQLite and I doubt many of them have ever found SQLite to be a bottleneck. Xojo dictionaries aren’t especially fast, so it wouldn’t surprise me at all if you found SQLite to be faster.